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KMID : 0359719960140030773
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Journal of the Korean Neurological Association
1996 Volume.14 No. 3 p.773 ~ p.780
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Serum Anti-Acetylcholine Receptor Antibody, Interleukin-2 and Soluble Interleukin-2 Receptor Levels in Myasthenia Gvavis
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임정근
박준형/유영수/이상도/박영춘
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Abstract
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Objective/Background:
@EN Serum levels of anti-acetylcholine receptor antibody (AChR-Ab), interleukin-2 (IL-2) and soluble interleukin-2 receptor (sIL-2R) may represent markers of disease severity in myasthenia gravis(MG). This study was performed to evaluate the
correlations between disease severity and immunological parameters such as serum AChR-Ab, IL-2 and sIL-2R level and between each immunological parameters.
@ES Methods:
@EN Serum levels of AChR-Ab, IL-2 and sIL-2R were measured in 30 MG patients and in 22 healthy controls.
@ES Results:
@EN Serum levels of AChR-Ab and sIL-2R were higher in MG than in healthy controls (p<0.01). The occurrence of IL-2 positive serum samples was 46.7% in MG but none in controls. There were no significant correlations between disease severity and
immunological parameters and between each immunological parameters.
@ES Conclusions:
@EN Serum IL-2 and sIL-2R levels may not represent markers of disease severity in MG. In order to further document the correlation between each parameters. follow-up of individual patients with serial serum samplings may be necessary.
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KEYWORD
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